ISHIN is by backed up by scientific research. We wanted to present scientific papers that support this.
[1] James Varani,* Michael K. Dame,* Laure Rittie,† Suzanne E.G. Fligiel,* Sewon Kang,† Gary J. Fisher,† and John J. Voorhees†. Decreased Collagen Production in Chronologically Aged Skin. Am J Pathol. 2006 Jun. [NCBI]
[2] Pamela Maher. The effects of stress and aging on glutathione metabolism. Ageing Res Rev. 2005 May;4(2):288-314. [PubMed]
[3] Hong-Tao Chen 1, Li-Ping Xie, Zhen-Yan Yu, Guang-Rui Xu, Rong-Qing Zhang. Chemical modification studies on alkaline phosphatase from pearl oyster (Pinctada fucata): a substrate reaction course analysis and involvement of essential arginine and lysine residues at the active site.Int J Biochem Cell Biol.. 2005 Jul;37(7):1446-57. [PubMed]
[4] Dai Jian-Ping 1, Chen Jun, Bei Yu-Fei, Han Bang-Xing, Guo Shang-Bin, Jiang Li-Li. Effects of pearl powder extract and its fractions on fibroblast function relevant to wound repair. Pharm Biol. . 2010 Feb;48(2):122-7. [PubMed]
[5] Sidharth Sonthalia 1, Deepashree Daulatabad, Rashmi Sarkar. Glutathione as a skin whitening agent: Facts, myths, evidence and controversies. Indian J Dermatol Venereol Leprol. May-Jun 2016;82(3):262-72. [PubMed]
[6] Sun Young Choi 1, Eun Jung Ko, Yong Hee Lee, Byung Gyu Kim, Hyun Jung Shin, Dae Bang Seo, Sang Jun Lee, Beom Joon Kim, Myeung Nam Kim. Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study. J Cosmet Laser Ther. 2014 Jun;16(3):132-7. [PubMed]
[7] Franchesca D. Choi, Calvin T. Sung, Margit L.W. Juhasz, Natasha Atanaskova Mesinkovsk. Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. J Drugs Dermatol. 2019 Jan 1;18(1):9-16. [PubMed]
[8] Sinee Weschawalit 1, Siriwan Thongthip 2, Phanupong Phutrakool 3, Pravit Asawanonda 1. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017 Apr 27;10:147-153. [PubMed]
[9] H.-F. Chiu, S.-C. Hsiao, Y.-Y. Lu, Y.-C. Han, Y.-C. Shen, K. Venkatakrishnan, C.-K. Wang. Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial. JOURNAL > Vol. 26 (2018) > Iss. 1. [JFDA] [ScienceDirect][PubMed]
[10] H.-L. Yang, M. Korivi, M.-K. Lin, H.C.-W. Chang, C.-R. Wu, M.-S. Lee, W.T.-L. Chen, Y.-C. Hseu. Antihemolytic and antioxidant properties of pearl powder against 2,2′-azobis(2-amidinopropane) dihydrochloride-induced hemolysis and oxidative damage to erythrocyte membrane lipids and proteins. JOURNAL > Vol. 25 (2017) > Iss. 4. [JFDA]
[11] Yi-Chen Li 1, Chi-Ruei Chen, Tai-Horng Young. Pearl extract enhances the migratory ability of fibroblasts in a wound healing model. Pharm Biol. 2013 Mar;51(3):289-97. [PubMed]
[12] Seetal Dodd 1, Olivia Dean, David L Copolov, Gin S Malhi, Michael Berk. N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opin Biol Ther. 2008 Dec;8(12):1955-62. [PubMed]
[13] Ines Elbini Dhouib 1, Manel Jallouli 2, Alya Annabi 2, Najoua Gharbi 2, Saloua Elfazaa 2, Mohamed Montassar Lasram 2. A minireview on N-acetylcysteine: An old drug with new approaches. Life Sci. 2016 Apr 15;151:359-363. [PubMed]
[14] B de Quay 1, R Malinverni, B H Lauterburg. Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine. AIDS. 1992 Aug;6(8):815-9. [PubMed]
[15] Anna Czajka 1, Ewa M Kania 2, Licia Genovese 3, Andrea Corbo 4, Giovanni Merone 5, Cecilia Luci 6, Sara Sibilla 7. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res. 2018 Sep;57:97-108. [PubMed]
[16] H.S. Chen J.H. Chang J.S.B. Wu. Calcium Bioavailability of Nanonized Pearl Powder for Adults. 03 November 2008. [Wiley]
[17] Xi Chen,Li-Hua Peng,Seng-Sing Chee,Ying-Hui Shan,Wen-Quan Liang &Jian-Qing Gao. Nanoscaled pearl powder accelerates wound repair and regeneration in vitro and in vivo. Pages 1009-1016 | Received 05 Sep 2018, Accepted 28 Feb 2019. [Taylor & Francis]
[18] Li-Ping Xie 1, Yuan-Tai Wu, Yi-Ping Dai, Qing Li, Rong-Qing Zhang. A novel glycosylphosphatidylinositol-anchored alkaline phosphatase dwells in the hepatic duct of the pearl oyster, Pinctada fucata. Mar Biotechnol (NY). Sep-Oct 2007;9(5):613-23. [PubMed]
[19]Tong ZH, Gu WZ, Zhu G, Zhao YW. “The anti-aging effect of pearl oyster shell powder (POSP).” Journal of Traditional Chinese Medicine. 1988 Dec;8(4):247-50. [NCBI]
[20] G Cao 1, Z Xu, H Wei, S Yao, Y Liu. Pearl and mother-of-pearl powder in health-care. Zhongguo Zhong Yao Za Zhi. 1996 Oct;21(10). [NCBI]
[21] Yijun Chen, WeishengTan, Zengping Qian, Zhenlun Gu, Jianxin Fan, Xinmei Zhuang: “Research on the anti-aging effects of pearl powder.” Senior Medicine Journal 8(2): 199, 1988.
[22] Zhi Xu, Derong Hu, Cai Cao, Huanying Wei, Shuhan Yao, Yuan Liu: “The effects of pearl on fruit fly’s life span and mice’s anti-radiation ability.” Chinese Medicine Journal 10(2): 29, 1998.
[23] Jian Wang, Dehui Hou: “The effect of pearl on free radical content and fruit fly’s life span.” Acta Academia Medicine Suzhou17(2): 218, 1997.
[24] Takujiro Homma 1, Junichi Fujii. Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs. 2015;16(7):560-71. [PubMed]
[25] Joseph Pizzorno. Glutathione! Integr Med (Encinitas). 2014 Feb; 13(1): 8–12. [NCBI]
[26] J S Bains 1, C A Shaw. Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res Brain Res Rev. 1997 Dec;25(3):335-58. [PubMed]
[27] 1Lasram MM, Dhouib IB, Annabi A, El Fazaa S, Gharbi N. A review on the possible molecular mechanism of action of N-acetylcysteine…. Clin Biochem. 2015 Nov;48(16-17):1200-8.
[28] 2Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther. 2014 Feb;141(2):150-9..
[29] Jung-Won Shin 1, Soon-Hyo Kwon 2, Ji-Young Choi 3 4, Jung-Im Na 5, Chang-Hun Huh 6, Hye-Ryung Choi 7, Kyung-Chan Park 8 9. Molecular Mechanisms of Dermal Aging and Antiaging Approaches. Int J Mol Sci. 2019 Apr 29;20(9):2126. [PubMed]
[30] Jérome Asserin 1, Elian Lati 2, Toshiaki Shioya 3, Janne Prawitt 4. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Randomized Controlled Trial J Cosmet Dermatol. 2015 Dec;14(4):291-301. [PubMed]
[31]E Proksch 1, D Segger, J Degwert, M Schunck, V Zague, S Oesser. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. [PubMed]
[32] Franchesca D. Choi, Calvin T. Sung, Margit L.W. Juhasz, Natasha Atanaskova Mesinkovsk. Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. J Drugs Dermatol. 2019 Jan 1;18(1):9-16. [PubMed]
[33] Ganggang Zhang 1, Alice Brion 1, Anne-Sophie Willemin 1, Marie-Hélène Piet 1, Vanessa Moby 1, Arnaud Bianchi 1, Didier Mainard 1, Laurent Galois 1, Pierre Gillet 1, Marthe Rousseau 1. Nacre, a natural, multi-use, and timely biomaterial for bone graft substitution. J Biomed Mater Res A
. 2017 Feb;105(2):662-671. [PubMed]
[34] M Lamghari 1, S Berland, A Laurent, H Huet, E Lopez. Bone reactions to nacre injected percutaneously into the vertebrae of sheep. Biomaterials
. 2001 Mar;22(6):555-62. [PubMed]
[35] G Atlan 1, O Delattre, S Berland, A LeFaou, G Nabias, D Cot, E Lopez. Interface between bone and nacre implants in sheep. Biomaterials
. 1999 Jun;20(11):1017-22. [PubMed]
[36] E Lopez 1, B Vidal, S Berland, S Camprasse, G Camprasse, C Silve. Demonstration of the capacity of nacre to induce bone formation by human osteoblasts maintained in vitro. Tissue Cell. 1992;24(5):667-79. [PubMed]
[37] Jing-Xian Zhang 1, Shang-Rong Li 1, Shuai Yao 1, Qi-Rui Bi 1, Jin-Jun Hou 1, Lu-Ying Cai 1, Su-Mei Han 1, Wan-Ying Wu 2, De-An Guo 1. Anticonvulsant and sedative-hypnotic activity screening of pearl and nacre (mother of pearl). J Ethnopharmacol. 2016 Apr 2;181:229-35.. [PubMed]
[38] John F Cryan 1, David A Slattery. GABAB receptors and depression. Current status. Adv Pharmacol. 2010;58:427-51. [PubMed]
[39] Meng Xia 1, Delun Huang 1, Yuangming Tong 2, Jiang Lin 1. Pearl powder reduces sleep disturbance stress response through regulating proteomics in a rat model of sleep deprivation. J Cell Mol Med. 2020 May;24(9):4956-4966. [PubMed]
[40] Vida Mokhtari, M.Sc,1,2,3 Parvaneh Afsharian, Ph.D,2 Maryam Shahhoseini, Ph.D,2 Seyed Mehdi Kalantar, Ph.D,1 and Ashraf Moini, M.D3,4,*. A Review on Various Uses of N-Acetyl Cysteine. Cell J. 2017 Apr-Jun; 19(1): 11–17. [NCBI]
[41] NAC BENEFITS [Health Line]
[42] Bernard Schmitt,a Morgane Vicenzi,b Catherine Garrel,c and Frédéric M. Denisb,⁎. Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study. Redox Biol. 2015 Dec; 6: 198–205. [NCBI]
[43] Jason Allen 1, Ryan D Bradley. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33. [PubMed]
